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    Salvia miltiorrhiza (Danshen) (丹参)
    danshen2.jpgdanshen1.jpg

    Salvia miltiorrhiza (simplified Chinese: 丹参; traditional Chinese: 丹參; pinyin: dānshēn), also known as red sage, Chinese sage, tan shen, or danshen, is a perennial plant in the genus Salvia, highly valued for its roots in traditional Chinese medicine. Native to China and Japan, it grows at 90 to 1,200 m (300 to 3,900 ft) elevation, preferring grassy places in forests, hillsides, and along stream banks. The specific epithet miltiorrhiza means "red juice extracted from a root".

    S. miltiorrhiza is a deciduous perennial with branching stems that are 30 to 60 cm (0.98 to 2.0 ft) tall, with widely spaced leaves that are both simple and divided. The .3 m (0.98 ft) inflorescences are covered with hairs and sticky glands. Flowers grow in whorls, with light purple to lavender blue corollas that are approximately 2.5 cm (0.082 ft) long, with a dark purple calyx. Salvia miltiorrhiza prefers well draining soil, with about half a day of sunlight. It is hardy to approximately −10 °C (14 °F). Most Salvia seeds have a higher germination rate when exposed to light, though it is not required.

    Salvia miltiorrhiza has been widely used in China and, to a lesser extent, in Japan, the United States, and European countries for the treatment of cardiovascular and cerebrovascular diseases. In China, the specific clinical use is angina pectoris, hyperlipidemia, and acute ischemic stroke.

    A patented Chinese herbal medicine has successfully completed Phase II clinical trials in the United States and will soon[when?] begin Phase III investigations,[citation needed] raising the possibility that it could become the first Traditional Chinese Medicine (TCM) product to obtain drug approval from the US Food and Drug Administration (FDA). The product, Compound Danshen Dripping Pill (also referred to as Cardiotonic Pill), is produced by Tianjin Tasly Pharmaceutical Co. Ltd. in Tianjin, China. It contains the extract of the root of danshen as well as extract of the root of notoginseng (Panax notoginseng; known as sanchi or tien-chi ginseng), and synthetic borneol, an active ingredient that replaces the more expensive natural borneol found in cardamom, ginger, and other spices.

    多年生草本,有丹红色肥大的根,俗称“红根”,茎高40~80厘米,多分枝,被长柔毛。叶常为奇数羽状复叶,顶端小叶较大,小叶卵形或椭圆状卵形, 先端钝,边缘具圆锯齿,两面被柔毛,下面较密。轮状聚伞花序成顶生或腋生,组成假总状花序,密被腺毛及长柔毛;小苞片披针形;花萼钟状,先端二唇形, 萼筒喉部密被白色柔毛;花冠蓝紫色,二唇形,花冠筒外伸,弯曲,筒内有毛环。椭圆形小坚果,花期5~8月,果期8~9月。

    性味归经
    味苦辛,性微寒。归心、心包絡、肝經。

    功能主治
    祛瘀止痛,活血通經,清心除煩,擴張血管。用於月经不调,闭经痛經,癥瘕積聚,產後惡露,胸腹刺痛,腸鳴腹痛,熱痹疼痛,瘡瘍腫痛,心煩不眠;肝脾腫大,心絞痛。一味丹參同四物湯,為女科要藥。



    基本信息
    【出处】《神农本草经》。

    【生境】生于山坡草地林边道旁,或疏林干燥地上。多为栽培,全国大部分地区均有。主产于四川、安徽、江苏、河南、山西等地。春、秋两季采挖,除去茎叶,洗净,润透,切成厚片,晒干。生用或酒炙用。

    【来源】该品为双子叶植物唇形科 Labiatae鼠尾草属植物丹参 Salvia miltiorrhiza Bge. 的干燥根及根茎。

    【性味】苦,微寒
    ①《本经》;味苦,微寒,无毒。
    ②《吴普本草》:岐伯:咸。
    ③李当之《药录》:大寒。
    ④《本草经疏》:味苦,平,微温。

    【归经】入心、肝经。
    ①《纲目》:手少阴、厥阴血分药。
    ②《本草经疏》:入手足少阴、足厥阴经。
    ③《本草正》:心、脾、肝、肾血分之药。

    【功效】活血调经,祛瘀止痛,凉血消痈,清心除烦,养血安神。
    ①《本经》:主心腹邪气,肠鸣幽幽如走水,寒热积聚;破症除瘕,止烦满,益气。
    ②《吴普本草》:治心腹痛。
    ③《别录》:养血,去心腹痼疾结气,腰脊强,脚痹;除风邪留热,久服利人。
    ④《云南中草药选》:活血散瘀,镇静止痛。治月经不调,痛经,风湿痹痛,子宫出血,吐血,乳腺炎,痈肿。
    ⑤《药性论》:治脚弱,疼痹,主中恶;治腹痛,气作声音呜吼。
    ⑥《日华子本草》:养神定志,通利关脉。治冷热劳,骨节疼痛,四肢不遂;排脓止痛,生肌长肉;破宿血,补新生血;安生胎,落死胎;止血崩带下,调妇人经脉不匀,血邪心烦;恶疮疥癣,瘿赘肿毒,丹毒;头痛,赤眼,热温狂闷。
    ⑦《滇南本草》:补心定志,安神宁心。治健忘怔冲,惊悸不寐。
    ⑧《纲目》:活血,通心包络。治疝痛。

    【主治】月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠;肝脾肿大,心绞痛。

    【应用】
    用于胸肋胁痛,风湿痹痛,症瘕结块,疮疡肿痛,跌仆伤痛,月经不调,经闭痛经,产后瘀痛等。治疗胸肋疼痛、症瘕结块,以及月经不调、经闭经痛具有良效,常与川芎配伍应用。在治疗胸腹疼痛属于气滞血瘀方面,往往配合砂仁、檀香等药同用。
    用于温病热入营血、身发斑疹、神昏烦躁。常与鲜地黄、水牛角、玄参等药同用。
    用于心悸怔忡、失眠。常与酸枣仁、柏子仁等药配合同用。【用法用量】煎服,9~15克。活血化瘀宜酒炙用。

    【使用注意】
    反藜芦。孕妇慎用。无瘀血者慎服。
    ①《本草经集庄》:畏咸水。反藜芦。
    ②《本草经疏》:妊娠无故勿服。
    ③《本草备要》:忌醋。
    ④《本经逢原》:大便不实者忌之。

    【不良反应】
    丹参-药用部分
    (1)个别患者会出现胃痛,食欲减少,口咽干燥,恶心呕吐,与丹参能抑制消化液的分泌有关。宜停药,并可口服胃舒平,普鲁苯辛等药,重者可皮下注射阿托品。
    (2)个别晚期血吸虫肝脾肿大患者,在服用大剂量丹参后会发生上消化道出血。应停用丹参,并给予止血剂,维生素等。
    (3)丹参可引起过敏反应,表现为全身皮肤瘙痒,皮疹,荨麻疹,有的还伴见胸闷憋气,呼吸困难,甚则恶寒,头晕,恶心呕吐,烦躁不安,随即面色苍白,肢冷汗出,血压下降,乃至昏厥休克等。应立即肌注肾上腺素或地塞米松以及非那根等抗过敏药,同时用中药生脉散加减调理。

    形态特征
    多年生草本,高30~100厘米,全株密布淡黄色柔毛及腺毛。根细长,圆柱形,外皮土红色。茎四棱形,上部分枝。叶对生,单数羽状复叶,小叶片卵圆形至宽卵圆形,两面密被白色柔毛。夏季开花,顶生和腋生的轮伞花序,每轮有花3~10朵,多轮排成疏离的总状花序;花萼略成钟状,紫色;花冠2唇形,蓝紫色,发育雄蕊2个,伸出花冠管外而盖于上唇之下,退化雄蕊2个,着生于上唇喉部的两侧;子房上位,4深裂,花柱较雄蕊长,柱头2裂片不相等。小坚果长圆形,熟时暗棕色或黑色,包于宿萼中。
    丹参别名

    【别名】赤参,山参,紫丹参,红根,红暖药,紫党参,红参,血参,血参根,血丹参,红丹参,赤丹参,血生根,血山根,木羊乳,连马,山红萝卜,活血根,靠山红,烧酒壶根,野苏子根,山苏子根,大红袍,蜜罐头,蜂糖罐,朵朵花根,却蝉草根,奔马草根,长鼠尾草根,水羊草根,红娘子根。

    【商品名】丹参。以根条粗壮,干燥、色紫红、无芦头及须根者为佳。

    【处方名】丹参,赤参,紫丹参,炒丹参,酒丹参,醋丹参,丹参炭,鳖血丹参等。

    丹参-中药材饮片
    处方中写丹参,赤参、紫丹参均指生丹参。为原药润透切片入药者。
    炒丹参为丹参片用文火炒至深黄色,略见焦斑,取出摊晾,而后入药者。
    酒丹参又名酒炒丹参。为丹参片用黄酒淋洒,闷透,文火微妙入药者。增强活血之功。
    醋丹参又名醋炒丹参。为丹参片用米醋淋洒,微闷,文火微炒入药者。增强止痛之功。
    丹参炭为丹参片用武火炒至焦黑,存性,清水灭尽火星。取出晾干,然后入药者。偏于止血。
    鳖血丹参又名鳖血拌丹参。为丹参片用适量鳖血拌匀,晾干后入药者。偏于养血。

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